B\u1ec7nh do virut herpes \u1edf ch\u00f3 l\u00e0 m\u1ed9t b\u1ec7nh truy\u1ec1n nhi\u1ec5m do alphaherpesvirus g\u00e2y ta r\u1ed1i lo\u1ea1n sinh s\u1ea3n. Virut c\u0169ng c\u00f3 th\u1ec3 th\u1ea5y trong h\u1ed9i ch\u1ee9ng \u201cho chu\u1ed3ng ch\u00f3\u201d. Sau khi nhi\u1ec5m, con v\u1eadt b\u1ecb bi\u1ebfn \u0111\u1ed5i huy\u1ebft thanh v\u00e0 tr\u1edf th\u00e0nh d\u01b0\u01a1ng t\u00ednh huy\u1ebft thanh. Sau \u0111\u00f3, n\u1ebfu b\u1ea3o h\u1ed9 mi\u1ec5n d\u1ecbch c\u1ee7a ch\u00f3 nhi\u1ec5m b\u1ec7nh \u0111\u1ee7 \u0111\u1ec3 ki\u1ec3m so\u00e1t nhi\u1ec5m tr\u00f9ng, virut s\u00e1t nh\u1eadp v\u00e0o ADN t\u1ebf b\u00e0o v\u00e0 ch\u00f3 tr\u1edf th\u00e0nh \u00e2m t\u00ednh huy\u1ebft thanh.<\/p>\n
Virut tr\u1edf th\u00e0nh \u201c\u1ea9n\u201d trong nhi\u1ec1u kh\u00ed quan v\u00e0 c\u00f3 th\u1ec3 t\u00e1i ho\u1ea1t \u0111\u1ed9ng v\u00e0o khi c\u00f3 \u201cstress\u201d ho\u1eb7c suy gi\u1ea3m mi\u1ec5n d\u1ecbch. T\u1ef7 l\u1ec7 virut tr\u00ean th\u1ebf gi\u1edbi r\u1ea5t cao, m\u1eb7c d\u00f9 nh\u1eefng nghi\u00ean c\u1ee9u v\u1ec1 t\u1ef7 l\u1ec7 huy\u1ebft thanh c\u00f2n \u00edt, nh\u01b0ng \u0111\u00e3 th\u1ea5y t\u1ef7 l\u1ec7 con v\u1eadt \u00e2m t\u00ednh huy\u1ebft thanh mang virut r\u1ea5t cao trong c\u00e1c b\u1ec7nh ph\u1ea9m m\u00e1u (hi\u1ec7n t\u01b0\u1ee3ng \u1ea9n). Virut t\u00e1i ho\u1ea1t \u0111\u1ed9ng \u1edf s\u1ed1 l\u1edbn ch\u00f3 do c\u00f3 stress ho\u1eb7c thi\u1ebfu v\u1ec7 sinh. Ch\u1ea9n \u0111o\u00e1n huy\u1ebft thanh h\u1ecdc c\u00f3 \u00edch \u0111\u1ec3 n\u1eafm b\u1eaft t\u00ecnh tr\u1ea1ng ch\u0103n nu\u00f4i h\u01a1n l\u00e0 ph\u00e1t hi\u1ec7n ra m\u1ed9t c\u00e1 th\u1ec3. Ng\u00e0y nay, t\u00ecm ADN virut b\u1eb1ng khu\u1ebfch \u0111\u1ea1i gen(PCR) l\u00e0 ph\u01b0\u01a1ng ph\u00e1p tin c\u1eady. V\u1ec1 ph\u00f2ng b\u1ec7nh, v\u1ec7 sinh ch\u0103n nu\u00f4i c\u00f3 vai tr\u00f2 ch\u1ee7 \u0111\u1ea1o. M\u1ed9t s\u1ed1 n\u01b0\u1edbc ti\u00eam vacxin nh\u01b0ng ph\u00f2ng b\u1ec7nh b\u1eb1ng huy\u1ebft thanh \u0111\u01b0\u1ee3c d\u00f9ng cho tr\u1ea1i c\u00f3 nguy c\u01a1.<\/p>\n
B\u1ec7nh do virut herpes \u1edf ch\u00f3 l\u00e0 m\u1ed9t b\u1ec7nh truy\u1ec1n nhi\u1ec5m do m\u1ed9t alphavirus herpes g\u00e2y n\u00ean, Canine herpesvirus (CHV), g\u00e2y ra c\u00e1c r\u1ed1i lo\u1ea1n sinh s\u1ea3n, ch\u1ee7 y\u1ebfu t\u1ed5n th\u1ea5t \u1edf ch\u00f3 con d\u01b0\u1edbi 3 tu\u1ea7n tu\u1ed5i v\u00e0 c\u00f3 th\u1ec3, m\u1eb7c d\u00f9 c\u00f2n nhi\u1ec1u tranh c\u00e3i, g\u00e2y n\u00e2n s\u1ed5i, s\u1ea9y thai v\u00e0 \/ho\u1eb7c ch\u1ebft s\u01a1 sinh. Virut c\u0169ng c\u00f3 th\u1ec3 th\u1ea5y trong h\u1ed9i ch\u1ee9ng \u201cho chu\u1ed3ng ch\u00f3\u201d.<\/p>\n
\u1ede M\u1ef9 n\u0103m 1964, ca b\u1ec7nh CHV \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c Carmichael m\u00f4 t\u1ea3 trong m\u1ed9t \u1ed5 ch\u00f3 con m\u1edbi sinh, tr\u01b0\u1edbc \u0111\u00f3 \u00f4ng \u0111\u00e3 cho l\u00e0 do c\u00e1c mycoplasma. Sau \u0111\u00f3 Spertzel v\u00e0 cs (1965), Stewart v\u00e0 cs (1965) v\u00e0 \u1edf Ph\u00e1p do Ratuld & Werner (1965) \u0111\u00e3 ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c virut \u1edf m\u1ed9t con ch\u00f3 Beagle nh\u1eadp kh\u1ea9u t\u1eeb Anh v\u00e0 ch\u00f3 \u0111\u00f3 b\u1ecb vi\u00eam m\u0169i v\u00e0 vi\u00eam ph\u1ebf qu\u1ea3n ph\u1ed5i.<\/p>\n
T\u1eeb nh\u1eefng n\u0103m 1990, b\u1ec7nh n\u00e0y \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u1edf nhi\u1ec1u n\u01b0\u1edbc tr\u00ean th\u1ebf gi\u1edbi v\u00e0 hai virut gi\u1ed1ng nhau \u0111\u00e3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y \u1edf kh\u00ed quan sinh d\u1ee5c v\u00e0 h\u00f4 h\u1ea5p. B\u1ec7nh n\u00e0y l\u00e0 m\u1ed1i quan t\u00e2m th\u1ef1c s\u1ef1 c\u1ee7a th\u00fa y v\u00e0 ng\u01b0\u1eddi nu\u00f4i.<\/p>\n
Nh\u1eefng n\u0103m g\u1ea7n \u0111\u00e2y, m\u1ed9t s\u1ed1 c\u00f4ng tr\u00ecnh \u0111\u00e3 th\u1eeba nh\u1eadn b\u1ec7nh n\u00e0y. B\u00e0i vi\u1ebft n\u00e0y nh\u1eb1m \u0111\u01b0a ra t\u1ed5ng h\u1ee3p thi\u1ebft th\u1ef1c cho c\u00e1c th\u00fa y.<\/p>\n
Virut g\u00e2y b\u1ec7nh ch\u1ee7 y\u1ebfu cho ch\u00f3 n\u00e0y thu\u1ed9c chi Varicellovirus, trong h\u1ecd ph\u1ee5 alphaherpesvirinae, r\u1ea5t gi\u1ed1ng virut herpes equine 1 v\u00e0 virut c\u1ee7a b\u1ec7nh th\u1ee7y \u0111\u1eadu v\u00e0 b\u1ec7nh zona (VZV). \u0110\u00e3 c\u00f3 16 ch\u1ee7ng virut herpes canine \u0111\u01b0\u1ee3c ph\u00e2n l\u1eadp tr\u00ean th\u1ebf gi\u1edbi, ch\u01b0a bao gi\u1edd x\u00e1c \u0111\u1ecbnh l\u00e0 l\u1eabn v\u1edbi c\u00e1c virut kh\u00e1c. So s\u00e1nh gen v\u1edbi c\u00e1c ch\u1ee7ng ph\u00e2n l\u1eadp kh\u00e1c cho th\u1ea5y virut n\u00e0y l\u00e0 \u0111\u01a1n typ (Decaro v\u00e0 cs 2008). Virut CHV c\u0169ng c\u00f2n \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 CHV-1 ho\u1eb7c CaHV-1.<\/p>\n
Virion c\u1ee7a CHV-1, \u0111\u01b0\u1eddng k\u00ednh t\u1eeb 115 \u0111\u1ebfn 175 nm, c\u00f3 m\u1ed9t s\u1ee3i \u0111\u00f4i ADN bao quanh nucl\u00e9ocapside, m\u1ed9t b\u00ec (t\u00e9gument) v\u00e0 m\u1ed9t v\u1ecf. Capside c\u00f3 \u0111\u1ed1i s\u1ee9ng hai m\u1eb7t \u0111i\u1ec3n h\u00ecnh c\u1ee7a virut herpes B\u00ec l\u00e0 1 prot\u00e9ine v\u00e0 v\u1ecf c\u00f3 m\u1ed9t m\u00e0ng lipid ph\u1ee7 b\u1ec1 m\u1eb7t c\u00e1c glycoprot\u00e9in g\u00e2y \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch, Nh\u1eefng prot\u00e9ine b\u1ec1 m\u1eb7t Gp 145\/112, Gp 80, Gp 41 l\u00e0 nh\u1eefng kh\u00e1ng nguy\u00ean ch\u1ee7 y\u1ebfu. Nh\u1eefng th\u00e0nh ph\u1ea7n lipid c\u1ee7a v\u1ecf gi\u1ea3i th\u00edch t\u00ednh nh\u1ea1y c\u1ea3m v\u1edbi c\u00e1c dung m\u00f4i lipid (chloroforme, \u00e9ther) v\u00e0 c\u00e1c thu\u1ed1c s\u00e1t tr\u00f9ng th\u01b0\u1eddng d\u00f9ng (chloramine, d\u1eabn xu\u1ea5t c\u1ee7a formald\u00e9hyde ph\u00e9nol h\u00f3a, ammonium b\u1ed1n nguy\u00ean t\u1ed1).<\/p>\n
\u0110\u1ec1 kh\u00e1ng v\u1edbi l\u1ea1nh, virut b\u1ec1n v\u1eefng \u1edf -700C, nh\u01b0ng kh\u1ea3 n\u0103ng g\u00e2y nhi\u1ec5m b\u1eaft \u0111\u1ea7u gi\u1ea3m \u0111i 24 gi\u1edd sau khi \u0111\u00e3 b\u1ecb gi\u1eef \u1edf 40C v\u00e0 5 ng\u00e0y sau khi \u1edf -200C. Virut nh\u1ea1y c\u1ea3m v\u1edbi nhi\u1ec7t, b\u1ecb b\u1ea5t ho\u1ea1t h\u1ea7u nh\u01b0 ngay l\u1eadp t\u1ee9c \u1edf 560C. Virut nh\u00e2n l\u00ean t\u1ed1t nh\u1ea5t gi\u1eefa 35 v\u00e0 360C, nh\u01b0ng n\u1ebfu gi\u1eef ch\u00fang \u1edf 370C trong n\u0103m gi\u1edd th\u00ec l\u00e0m gi\u1ea3m kh\u1ea3 n\u0103ng g\u00e2y nhi\u1ec5m \u0111i t\u1edbi 10.000 l\u1ea7n. B\u1ecb b\u1ea5t ho\u1ea1t \u1edf pH acid, n\u00f3 c\u00f2n b\u1ec1n v\u1eefng v\u1edbi pH gi\u1eefa 6,5 v\u00e0 7,6. V\u00ec th\u1ebf n\u00f3 k\u00e9m \u0111\u1ec1 kh\u00e1ng v\u1edbi m\u00f4i tr\u01b0\u1eddng b\u00ean ngo\u00e0i.<\/p>\n
V\u1ec1 ph\u00e1t sinh lo\u00e0i, tr\u01b0\u1edbc h\u1ebft virut g\u1ea7n v\u1edbi herpesvirus feline 1 v\u00e0 virut herpes h\u1ea3i c\u1ea9u 1. Ng\u01b0\u1eddi ta t\u00ecm th\u1ea5y c\u00e1c gen gi\u1ed1ng v\u1edbi c\u00e1c gen c\u1ee7a c\u00e1c alphavirus herpes kh\u00e1c, nh\u01b0 virut herpes bovine 1, herpes simplex 1, virut VZV v\u00e0 virut c\u1ee7a b\u1ec7nh Aujeszky (Ronsse v\u00e0 cs,2003).<\/p>\n<\/p>\n
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B\u1ec7nh do virut herpes \u1edf ch\u00f3 l\u00e0 m\u1ed9t b\u1ec7nh truy\u1ec1n nhi\u1ec5m do alphaherpesvirus g\u00e2y ta r\u1ed1i lo\u1ea1n sinh s\u1ea3n. Virut c\u0169ng c\u00f3 th\u1ec3 th\u1ea5y trong h\u1ed9i ch\u1ee9ng \u201cho chu\u1ed3ng ch\u00f3\u201d. Sau khi nhi\u1ec5m, con v\u1eadt b\u1ecb bi\u1ebfn \u0111\u1ed5i huy\u1ebft thanh v\u00e0 tr\u1edf th\u00e0nh d\u01b0\u01a1ng t\u00ednh huy\u1ebft thanh. Sau \u0111\u00f3, n\u1ebfu b\u1ea3o h\u1ed9 mi\u1ec5n d\u1ecbch c\u1ee7a […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1289","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/posts\/1289","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/comments?post=1289"}],"version-history":[{"count":0,"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/posts\/1289\/revisions"}],"wp:attachment":[{"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/media?parent=1289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/categories?post=1289"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/tags?post=1289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}