{"id":2269,"date":"2018-11-19T13:56:15","date_gmt":"2018-11-19T13:56:15","guid":{"rendered":"https:\/\/robot.yeupet.vn\/benh-truyen-nhiem-do-papillomavirus-tren-cho-meo-benh-u-nhu\/"},"modified":"2018-11-19T13:56:15","modified_gmt":"2018-11-19T13:56:15","slug":"benh-truyen-nhiem-do-papillomavirus-tren-cho-meo-benh-u-nhu","status":"publish","type":"post","link":"https:\/\/robot.yeupet.vn\/index.php\/2018\/11\/19\/benh-truyen-nhiem-do-papillomavirus-tren-cho-meo-benh-u-nhu\/","title":{"rendered":"B\u1ec7nh Truy\u1ec1n Nhi\u1ec5m Do Papillomavirus Tr\u00ean Ch\u00f3 M\u00e8o \u2013 B\u1ec7nh U Nh\u00fa"},"content":{"rendered":"

1. NGUY\u00caN NH\u00c2N<\/strong><\/span>
\nL\u00e0 do virus thu\u1ed9c th\u00e0nh vi\u00ean c\u1ee7a Papillomavirus (PV) v\u1edbi k\u00edch th\u01b0\u1edbc r\u1ea5t nh\u1ecf (30-60 nm), l\u00e0 virus kh\u00f4ng c\u00f3 v\u1ecf envelope v\u1edbi hai m\u01b0\u01a1i m\u1eb7t \u0111\u1ed1i x\u1ee9ng v\u00e0 b\u1ed9 gen v\u00f2ng AND. Ch\u00fang c\u00f3 c\u00f9ng ph\u00e2n lo\u1ea1i v\u1edbi polyomaviruses, trong gia \u0111\u00ecnh Papovaviridae. Ch\u00fang thi\u1ebfu m\u1ed9t l\u1edbp v\u1ecf envelope. PV l\u00e0 ph\u1ed5 bi\u1ebfn trong t\u1ef1 nhi\u00ean v\u00e0 l\u00e2y nhi\u1ec5m sang nhi\u1ec1u lo\u00e0i \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa v\u00e0 chim. Ch\u00fang g\u00e2y b\u1ec7nh v\u1edbi v\u1eadt ch\u1ee7 r\u1ea5t \u0111\u1eb7c hi\u1ec7u, v\u00e0 s\u1ef1 sao ch\u00e9p c\u1ee7a ch\u00fang <\/span>\u0111\u01b0\u1ee3c li\u00ean k\u1ebft ch\u1eb7t ch\u1ebd v\u1edbi t\u1ebf b\u00e0o v\u1eadt ch\u1ee7 chuy\u00ean bi\u1ec7t. V\u00ed d\u1ee5, th\u1ef1c hi\u1ec7n c\u1ea5y u nh\u00fa \u1edf mi\u1ec7ng ch\u00f3 (COPV \u2013 canine oral papillomavirus) v\u00e0o cho m\u00e8o, chu\u1ed9t, chu\u1ed9t, chu\u1ed9t lang, th\u1ecf v\u00e0 \u0111\u1ed9ng v\u1eadt linh tr\u01b0\u1edfng (kh\u00f4ng ph\u1ea3i l\u00e0 con ng\u01b0\u1eddi) \u0111\u00e3 cho th\u1ea5y th\u1ea5t b\u1ea1i trong vi\u1ec7c s\u1ea3n xu\u1ea5t u nh\u00faPV \u1edf \u0111\u1ed9ng v\u1eadt g\u00e2y ra tr\u00ean da l\u00e0nh t\u00ednh v\u00e0 s\u1ef1 gia t\u0103ng ni\u00eam m\u1ea1c th\u00f4ng th\u01b0\u1eddng c\u00f3 s\u1ef1 t\u1ef1 gi\u1edbi h\u1ea1n v\u00e0 hi\u1ebfm khi ti\u1ebfn tri\u1ec3n th\u00e0nh c\u00e1c kh\u1ed1i u \u00e1c t\u00ednh. M\u1eb7t kh\u00e1c PV \u1edf ng\u01b0\u1eddi (HPV \u2013 human papillomavirus ) , t\u1ea1o ra m\u1ed9t nhi\u1ec5m tr\u00f9ng ph\u1ea1m vi r\u1ed9ng, m\u1ed9t trong s\u1ed1 \u0111\u00f3 l\u00e0 s\u1ed1ng h\u1ed9i sinh, trong khi m\u1ed9t s\u1ed1 kh\u00e1c g\u00e2y ra bi\u1ebfn \u0111\u1ed5i ung th\u01b0, \u0111\u1eb7c bi\u1ec7t l\u00e0 tr\u00ean c\u00e1c ch\u1ea5t m\u00e0ng nh\u1ea7y. Hi\u1ec7n nay \u0111\u00e3 ph\u00e2n l\u1eadp \u0111\u01b0\u1ee3c 7 ch\u1ee7ng tr\u00ean ch\u00f3 v\u00e0 2 ch\u1ee7ng tr\u00ean m\u00e8o.<\/p>\n

\"benh-truyen-nhiem-do-papillomavirus-tren-cho-meo-benh-u-nhu\"<\/p>\n

2. D\u1ecaCH T\u1ec2 H\u1eccC<\/strong><\/p>\n

HPV x\u00e2m nh\u1eadp v\u00e0o trong bi\u1ec3u m\u00f4 v\u1ea3y c\u00f3 th\u1ec3 g\u00e2y nhi\u1ec5m tr\u00f9ng ti\u1ec1m \u1ea9n, kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng v\u00e0 c\u00e1c b\u1eb1ng ch\u1ee9ng vi th\u1ec3 c\u1ee7a b\u1ec7nh. Khi nhi\u1ec5m tr\u00f9ng \u0111\u01b0\u1ee3c th\u1ec3 hi\u1ec7n, c\u00e1c ph\u00e2n t\u1eed g\u00e2y truy\u1ec1n nhi\u1ec5m \u0111\u00f2i h\u1ecfi ph\u1ea3i th\u00e2m nh\u1eadp v\u00e0o c\u00e1c t\u1ebf b\u00e0o trong l\u1edbp \u0111\u00e1y, trong nhi\u1ec1u tr\u01b0\u1eddng h\u1ee3p g\u00e2y ph\u00e1 v\u1ee1 bi\u1ec3u m\u00f4. Tuy nhi\u00ean, trong c\u00e1c tr\u01b0\u1eddng h\u1ee3p , nhi\u1ec5m tr\u00f9ng \u0111\u1ea7u ti\u00ean l\u00e0 k\u1ebft qu\u1ea3 c\u1ee7a m\u1ed9t giai \u0111o\u1ea1n \u1ee7 b\u1ec7nh c\u1ee7a virus tr\u01b0\u1edbc \u0111\u00f3, trong \u0111\u00f3 gen c\u1ee7a virus tr\u1ea3i qua s\u1ef1 sao ch\u00e9p nh\u01b0 c\u00e1c y\u1ebfu t\u1ed1 \u0111\u1ed9c l\u1eadp kh\u00f4ng ph\u1ee5 thu\u1ed9c di truy\u1ec1n nhi\u1ec5m s\u1eafc th\u1ec3.
\nPh\u01b0\u01a1ng ph\u00e1p c\u1eadn l\u00e2m s\u00e0ng c\u1ee7a b\u1ec7nh PV \u1edf ch\u00f3 v\u00e0 m\u00e8o l\u00e0 kh\u00f4ng ch\u1eafc ch\u1eafn v\u00e0 kh\u00f4ng ph\u1ed5 bi\u1ebfn. Tuy nhi\u00ean, trong m\u1ed9t nghi\u00ean c\u1ee9u huy\u1ebft thanh, 49 7,4% \u0111\u1ebfn 50,2% con ch\u00f3 kh\u1ecfe m\u1ea1nh \u0111\u00e3 c\u00f3 kh\u00e1ng th\u1ec3 ch\u1ed1ng l\u1ea1i COPV v\u00e0\/ho\u1eb7c CdPV3. \u0110\u1ed1i v\u1edbi tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n, PV ph\u1ea3i v\u01b0\u1ee3t qua c\u00e1c ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch c\u1ee7a v\u1eadt ch\u1ee7 \u0111\u1ec3 sao ch\u00e9p, v\u00ec v\u1eady t\u1ea7m quan tr\u1ecdng trong nhi\u1ec5m tr\u00f9ng PV l\u00e0 tr\u00ean nh\u1eefng th\u00fa b\u1ec7nh suy gi\u1ea3m mi\u1ec5n d\u1ecbch. Kh\u1ea3 n\u0103ng mi\u1ec5n d\u1ecbch v\u1ed1n c\u00f3, cho th\u1ea5y khuynh h\u01b0\u1edbng gi\u1ed1ng r\u00f5 r\u00e0ng cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a m\u1ed9t \u0111i\u1ec1u ki\u1ec7n c\u1ee5 th\u1ec3 c\u1ee7a PV li\u00ean quan \u0111\u1ebfn ch\u00f3, c\u1ee5 th\u1ec3 l\u00e0 m\u1ea3ng s\u1eafc t\u1ed1, \u0111\u00e3 \u0111\u01b0\u1ee3c th\u00e0nh l\u1eadp \u1edf ch\u00f3 pugs. T\u01b0\u01a1ng t\u1ef1 nh\u01b0 v\u1eady, ch\u00f3 coocker spaniels tr\u01b0\u1edfng th\u00e0nh v\u00e0 ch\u00f3 Kerry blue terriers c\u00f3 th\u1ec3 d\u1ec5 b\u1ecb papillomas da.
\nC\u1ea3i ti\u1ebfn k\u1ef9 thu\u1eadt ph\u00e1t hi\u1ec7n \u0111\u00e3 cho ph\u00e9p ph\u00e1t hi\u1ec7n kh\u00f4ng ch\u1ec9 c\u00e1c \u0111\u1eb7c t\u00ednh c\u1ee7a \u0111\u1ed9ng v\u1eadt \u0103n th\u1ecbt PV m\u00e0 c\u00f2n l\u00e0 ph\u00e1t hi\u1ec7n s\u1ef1 m\u1edbi l\u1ea1 c\u1ee7a acid nucleic trong m\u1ed9t lo\u1ea1t c\u00e1c t\u1ed5n th\u01b0\u01a1ng da nh\u01b0 t\u1ea1i ch\u1ed7 v\u00e0 x\u00e2m l\u1ea5n t\u1ebf b\u00e0o v\u1ea3y ung th\u01b0 bi\u1ec3u m\u00f4 (SCCs \u2013 squamous cell carcinomas). Tuy nhi\u00ean, v\u1edbi x\u00e9t nghi\u1ec7m PCR hi\u1ec7n nay c\u00f3 th\u1ec3 ph\u00e1t hi\u1ec7n m\u1ed9t b\u1ea3n sao gen PV trong s\u1ed1 100 t\u1ebf b\u00e0o s\u1eebng. Trong th\u1ef1c t\u1ebf, qu\u00e1 \u00edt virus \u0111\u1ec3 c\u00f3 th\u1ec3 c\u00f3 kh\u1ea3 n\u0103ng g\u00e2y b\u1ea5t k\u1ef3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n t\u00e2n sinh trong c\u00e1c m\u00f4 ch\u1ee9a ch\u1ea5p l\u00e0 r\u1ea5t \u0111\u00e1ng nghi ng\u1edd, ph\u1ea3i gi\u1ea3i th\u00edch r\u1ea5t c\u1ea9n th\u1eadn b\u1ea5t k\u1ef3 k\u1ebft qu\u1ea3 d\u01b0\u01a1ng t\u00ednh thu \u0111\u01b0\u1ee3c v\u1edbi c\u00e1c x\u00e9t nghi\u1ec7m nh\u01b0 v\u1eady. V\u00ed d\u1ee5, s\u1eed d\u1ee5ng ph\u00e1t hi\u1ec7n PCR, ph\u00e1t hi\u1ec7n FdPV2 \u0111\u00e3 \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong da c\u1ee7a 52% m\u00e8o kh\u1ecfe m\u1ea1nh v\u1ec1 m\u1eb7t l\u00e2m s\u00e0ng, b\u1ea5t k\u1ec3 tu\u1ed5i t\u00e1c, gi\u1edbi t\u00ednh c\u1ee7a ch\u00fang ho\u1eb7c b\u1ecb nhi\u1ec5m FIV.
\nNg\u01b0\u1ee3c l\u1ea1i, k\u1ebft qu\u1ea3 d\u01b0\u01a1ng t\u00ednh thu \u0111\u01b0\u1ee3c v\u1edbi k\u1ef9 thu\u1eadt c\u0169, nh\u01b0 h\u00f3a m\u00f4 mi\u1ec5n d\u1ecbch (IHC \u2013 immunohistochemistry) l\u00e0 c\u00f3 \u00fd ngh\u0129a h\u01a1n cho \u0111\u1ebfn nay. X\u00e9t nghi\u1ec7m d\u01b0\u01a1ng t\u00ednh ch\u1ec9 khi m\u1ed9t s\u1ed1 ti\u1ec1n ch\u1ea5t proteinc\u1ee7a capsid virus c\u00f3 m\u1eb7t trong m\u1eabu. Do \u0111\u00f3, khi k\u1ebft qu\u1ea3 d\u01b0\u01a1ng, c\u00e1c x\u00e9t nghi\u1ec7m IHC, th\u1ec3 hi\u1ec7n kh\u00f4ng ch\u1ec9 s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a virus m\u00e0 c\u00f2n cho th\u1ea5y ho\u1ea1t \u0111\u1ed9ngsao ch\u00e9p c\u1ee7a n\u00f3, v\u1edbi nhi\u1ec1u kh\u1ea3 n\u0103ng l\u00e0 c\u1ea3 bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng. K\u1ebft qu\u1ea3 d\u01b0\u01a1ng t\u00ednh IHC \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh trong m\u1ee5n c\u00f3c ch\u00f3, m\u1ea3ng s\u1eafc t\u1ed1 c\u1ee7a lo\u00e0i ch\u00f3, m\u1ea3ng virus, v\u00e0 m\u00e8o BISC. Ngo\u00e0i ra,DNA PV \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 m\u1eb7t \u1edf h\u1ea7u h\u1ebft (17\/20) da m\u00e8o c\u00f3 SCC v\u00e0 hi\u1ebfm (1\/20) \u0111\u1ed1i v\u1edbi SCC \u1edfmi\u1ec7ng.<\/p>\n

3. SINH B\u1ec6NH H\u1eccC<\/strong><\/p>\n

Chu tr\u00ecnh s\u1ed1ng c\u1ee7a PV th\u01b0\u1eddng \u0111\u01b0\u1ee3c gi\u1edbi h\u1ea1n trong c\u00e1c l\u1edbp bi\u1ec3u b\u00ec v\u00e0 bi\u1ec3u m\u00f4 v\u00e0 li\u00ean k\u1ebft ch\u1eb7t ch\u1ebd v\u1edbi c\u00e1c t\u1ebf b\u00e0o bi\u1ec3u m\u00f4 kh\u00e1c bi\u1ec7t. Gen HPV s\u1edbm (gen E) \u0111\u01b0\u1ee3c th\u1ec3 hi\u1ec7n \u1edf c\u1ea5p \u0111\u1ed9 \u0111\u00e1y v\u00e0 \u1edf tr\u00ean \u0111\u00e1y c\u1ee7a c\u00e1c l\u1edbp bi\u1ec3u b\u00ec, trong khi gen mu\u1ed9n (L1 v\u00e0 L2) \u0111\u01b0\u1ee3c th\u1ec3 hi\u1ec7n trong c\u00e1c l\u1edbp t\u1ebf b\u00e0o gai v\u00e0 t\u1ebf b\u00e0o h\u1ea1t. Sau khi nhi\u1ec5m b\u1ec7nh, t\u0103ng s\u1ea3n trong t\u1ea7ng gai x\u1ea3y ra, v\u00e0 s\u1ef1 gia t\u0103ng c\u1ee7a bi\u1ec3u m\u00f4 (gai, t\u0103ng s\u1eebng, v\u1edbi s\u1ef1 h\u00ecnh th\u00e0nh m\u1ee5n c\u00f3c) tr\u1edf th\u00e0nh tri\u1ec7u ch\u1ee9ng l\u00e2m s\u00e0ng r\u00f5 r\u00e0ng khi 4-6 tu\u1ea7n.
\nM\u1ee5n c\u00f3c tho\u00e1i h\u00f3a t\u1ef1 ph\u00e1t l\u00e0 qu\u00e1 tr\u00ecnh b\u00ecnh th\u01b0\u1eddng, x\u1ea3y ra sau 6-8 tu\u1ea7n. M\u1ee5n c\u00f3c tho\u00e1i h\u00f3a th\u01b0\u1eddng \u0111\u01b0\u1ee3c quan s\u00e1t th\u1ea5y \u1edf nh\u1eefng con ch\u00f3 con, trong khi \u0111\u00f3 nhi\u1ec5m tr\u00f9ng PV dai d\u1eb3ng \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o ch\u1ee7 y\u1ebfu \u1edf ch\u00f3 tr\u01b0\u1edfng th\u00e0nh. C\u00e1c t\u1ed5n th\u01b0\u01a1ng tr\u00ean m\u00e8o con 6-7 th\u00e1ng tu\u1ed5i \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o, nh\u01b0ng h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p l\u00e0 \u1edf m\u00e8o 6-13 tu\u1ed5i. Suy gi\u1ea3m mi\u1ec5n d\u1ecbch c\u00f3 li\u00ean quan kh\u00f4ng ch\u1ec9 v\u1edbi t\u0103ng c\u01a1 h\u1ed9i bi\u1ec3u hi\u1ec7n l\u00e2m s\u00e0ng m\u00e0 c\u00f2n v\u1edbi nhi\u1ec5m tr\u00f9ng dai d\u1eb3ng v\u00e0 chuy\u1ec3n sang ung th\u01b0.
\nS\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a kh\u00e1ng th\u1ec3 trung h\u00f2a \u1edf ch\u00f3 sau khi m\u1ee5n c\u00f3c suy tho\u00e1i t\u1eeb l\u00e2u \u0111\u00e3 \u0111\u01b0\u1ee3c c\u00f4ng nh\u1eadn. C\u00e1c kh\u00e1ng th\u1ec3 ng\u0103n ng\u1eeba t\u00e1i nhi\u1ec5m PV c\u00f3 trong h\u1ea7u h\u1ebft c\u00e1c con ch\u00f3, nh\u01b0ng kh\u00f4ng l\u00e0m tho\u00e1i h\u00f3a c\u1ee7a c\u00e1c kh\u1ed1i u \u0111\u00e3 h\u00ecnh th\u00e0nh. \u0110i\u1ec1u n\u00e0y cho th\u1ea5y s\u1ef1 suy tho\u00e1i c\u00e1c kh\u1ed1i u c\u00f3 li\u00ean quan \u0111\u1ebfn m\u1ed9t ph\u1ea3n \u1ee9ng trung gian t\u1ebf b\u00e0o. Gi\u1ea3 thuy\u1ebft n\u00e0y \u0111\u01b0\u1ee3c h\u1ed7 tr\u1ee3 b\u1edfi s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a lympho th\u00e2m nh\u1eadp trong h\u1ea7u h\u1ebft c\u00e1c m\u1ee5n c\u00f3c suy tho\u00e1i \u1edf ch\u00f3 v\u00e0 nhi\u1ec1u lo\u00e0i kh\u00e1c.
\nC\u00e1c \u0111\u1ed9ng v\u1eadt \u0103n th\u1ecbt c\u00f3PV mang gen g\u00e2y ung th\u01b0 (E6, E7, E5), nh\u01b0ng cu\u1ed1i c\u00f9ng bi\u1ec3u hi\u1ec7n c\u1ee7a c\u00e1c gen n\u00e0y c\u00f3 th\u1ec3 ph\u1ee5 thu\u1ed9c v\u00e0o s\u1ef1 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch v\u1eadt ch\u1ee7. Goldschmidt v\u00e0 \u0111\u1ed3ng nghi\u1ec7p, \u0111\u00e3 c\u00f4 l\u1eadp t\u1eeb CdPV2 c\u1ee7a gi\u1ed1ng ch\u00f3 s\u0103n beagle b\u1ecb suy gi\u1ea3m mi\u1ec5n d\u1ecbch.<\/p>\n

4. PH\u00c1T HI\u1ec6N L\u00c2M S\u00c0NG<\/strong><\/p>\n

Ch\u00f3<\/strong>
\nTh\u00f4ng th\u01b0\u1eddng m\u1ee5n c\u00f3c x\u1ea3y ra \u1edf ch\u00f3 con (H\u00ecnh 1). Ni\u00eam m\u1ea1c mi\u1ec7ng ch\u1ee7 y\u1ebfu b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi \u0111i\u1ec1u ki\u1ec7n COPV-li\u00ean k\u1ebft. M\u00ed m\u1eaft, m\u00f4i, th\u1ef1c qu\u1ea3n, v\u00e0 da l\u00f4ng c\u0169ng c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng th\u1ee9 ph\u00e1t. Tho\u00e1i h\u00f3a th\u01b0\u1eddng x\u1ea3y ra trong v\u00f2ng m\u1ed9t v\u00e0i tu\u1ea7n. Da ch\u00f3 tr\u01b0\u1edfng th\u00e0nh c\u0169ng c\u00f3 th\u1ec3 b\u1ecb \u1ea3nh h\u01b0\u1edfng b\u1edfi c\u00e1c h\u00ecnh th\u1ee9c kh\u00e1c c\u1ee7a papillomatosis, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u0111\u1ec7m b\u00e0n ch\u00e2n v\u00e0 ph\u1ea7n r\u00eca da. Kerry blue terriers v\u00e0 spaniels cocker c\u00f3 th\u1ec3 th\u01b0\u1eddng g\u1eb7p PV, gi\u1ed1ng ch\u00f3 pug \u0111\u01b0\u1ee3c coi l\u00e0 d\u1ec5 m\u1eafc c\u00e1c m\u1ea3ng b\u00e1m. Tobler v\u00e0 \u0111\u1ed3ng nghi\u1ec7p \u0111\u00e3 ch\u1ee9ng minh r\u1eb1ng b\u1ed1n pugs ch\u1ecbu \u1ea3nh h\u01b0\u1edfng \u0111\u00e3 b\u1ecb nhi\u1ec5m b\u1ec7nh do c\u00f9ng PV, c\u1ee5 th\u1ec3 l\u00e0 CdPV4. C\u00e1c PV tr\u00ean ch\u00f3, c\u1ee5 th\u1ec3 l\u00e0 CdPV3, CPV5, v\u00e0 CdPV7. Papillomas \u0111\u1ea3o ng\u01b0\u1ee3c l\u00e0 m\u1ee5n c\u00f3c ph\u00e1t tri\u1ec3n \u0111i xu\u1ed1ng v\u00e0o trong da. K\u1ebft qu\u1ea3 l\u00e0 ph\u00e1t tri\u1ec3n n\u1ed1t s\u1ea7n m\u1ecbn, th\u01b0\u1eddng l\u00e0 1-2 cm \u0111\u01b0\u1eddng k\u00ednh, v\u1edbi m\u1ed9t l\u1ed7 trung t\u00e2m ch\u1ee9a \u0111\u1ea7y ch\u1ea5t s\u1eebng (H\u00ecnh 2). Ch\u00fang th\u01b0\u1eddng x\u1ea3y ra tr\u00ean b\u1ee5ng v\u00e0 c\u00f3 th\u1ec3 \u0111\u01a1n \u0111\u1ed9c hay nhi\u1ec1u. S\u1ef1 suy tho\u00e1i t\u1ef1 ph\u00e1t l\u00e0 kh\u00f4ng ph\u1ed5 bi\u1ebfn, v\u00e0 ph\u1eabu thu\u1eadt l\u00e0 l\u1ef1a ch\u1ecdn \u0111i\u1ec1u tr\u1ecb.<\/p>\n

\"benh-truyen-nhiem-do-papillomavirus-tren-cho-meo-benh-u-nhu1\"<\/p>\n

\u00a0\"benh-truyen-nhiem-do-papillomavirus-tren-cho-meo-benh-u-nhu2\"<\/span><\/p>\n

M\u00e8o<\/strong>
\nS\u1ef1 xu\u1ea5t hi\u1ec7n th\u01b0\u1eddng th\u1ea5y tr\u00ean m\u00e8o, v\u1edbi PV c\u1ea3m \u1ee9ng c\u00e1c t\u1ed5n th\u01b0\u01a1ng, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 m\u1ea3ng b\u00e1m virus, kh\u00f4ng ph\u1ea3i l\u00e0 \u0111i\u1ec3n h\u00ecnh c\u1ee7a papillomas th\u1ea5y \u1edf \u0111\u1ed9ng v\u1eadt nu\u00f4i kh\u00e1c. M\u1ea3ng b\u00e1m c\u00f3 th\u1ec3 c\u00f3 m\u00e0u tr\u1eafng ho\u1eb7c s\u1eafc t\u1ed1 v\u00e0 c\u00f3 v\u1ea3y v\u00e0 nh\u1edbt khi ch\u1ea1m v\u00e0o. C\u00e1c t\u1ed5n th\u01b0\u01a1ng th\u01b0\u1eddng c\u1ee5c b\u1ed9 \u1edf \u0111\u1ea7u, c\u1ed5, l\u01b0ng m\u1ed9t ph\u1ea7n c\u1ee7a ng\u1ef1c, v\u00e0 b\u1ee5ng. Sarcoids m\u00e8o l\u00e0 c\u00e1c t\u1ed5n th\u01b0\u01a1ng hi\u1ebfm x\u1ea3y ra tr\u00ean m\u0169i, ng\u00f3n ch\u00e2n, m\u00f4i, loa tai, v\u00e0 \u0111u\u00f4i. M\u00e8o th\u00f4ng th\u01b0\u1eddng c\u00f2n nh\u1ecf, v\u00e0 s\u1ed1ng tr\u1eddi s\u1ed1ng trong m\u1ed9t m\u00f4i tr\u01b0\u1eddng n\u00f4ng th\u00f4n (th\u01b0\u1eddng ti\u1ebfp x\u00fac v\u1edbi gia s\u00fac) c\u00f3 xu h\u01b0\u1edbng th\u01b0\u1eddng xuy\u00ean b\u1ecb \u1ea3nh h\u01b0\u1edfng h\u01a1n.<\/p>\n

5. CH\u1ea8N \u0110O\u00c1N<\/strong><\/p>\n

Ch\u1ea9n \u0111o\u00e1n papillomatosis \u0111\u01b0\u1ee3c d\u1ef1a tr\u00ean d\u1ecbch t\u1ec5 h\u1ecdc v\u00e0 t\u1ed5ng s\u1ed1 xu\u1ea5t hi\u1ec7n c\u1ee7a c\u00e1c kh\u1ed1i u. M\u1ed9t sinh thi\u1ebft v\u1edbi \u0111\u1ea7y \u0111\u1ee7 \u0111\u1ed9 d\u00e0y c\u1ee7a to\u00e0n b\u1ed9 t\u1ed5n th\u01b0\u01a1ng c\u1ea3 v\u00f9ng b\u00ecnh th\u01b0\u1eddng l\u00e2n c\u1eadn c\u0169ng c\u1ea7n \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n v\u00e0 x\u1eed l\u00fd cho m\u00f4 b\u1ec7nh h\u1ecdc, IHC, ho\u1eb7c ki\u1ec3m tra k\u00ednh hi\u1ec3n vi \u0111i\u1ec7n t\u1eed. Ph\u01b0\u01a1ng ph\u00e1p x\u00e9t nghi\u1ec7m PCR c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n \u0111\u1ec3 ch\u1ee9ng minh s\u1ef1 hi\u1ec7n di\u1ec7n c\u1ee7a DNA PVtrong c\u00e1c t\u1ed5n th\u01b0\u01a1ng, c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh ch\u1ee7ng lo\u1ea1i PV.<\/p>\n

6. \u0110I\u1ec0U TR\u1eca<\/strong><\/p>\n

Trong th\u1ef1c t\u1ebf, s\u1ef1 suy tho\u00e1i t\u1ef1 ph\u00e1t c\u1ee7a h\u1ea7u h\u1ebft c\u00e1c u nh\u00fa \u1edf mi\u1ec7ng ch\u00f3 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u00fa \u00fd. Tho\u00e1i lui c\u1ee7a c\u00e1c t\u1ed5n th\u01b0\u01a1ng th\u01b0\u1eddng x\u1ea3y ra trong v\u00f2ng 3 th\u00e1ng m\u00e0 kh\u00f4ng c\u1ea7n \u0111i\u1ec1u tr\u1ecb. S\u1ef1 b\u1ec1n b\u1ec9 (sau h\u01a1n 4 th\u00e1ng) s\u1ebd th\u00fac \u0111\u1ea9y vi\u1ec7c \u0111\u00e1nh gi\u00e1 l\u1ea1i t\u00ecnh tr\u1ea1ng mi\u1ec5n d\u1ecbch c\u1ee7a con ch\u00f3 b\u1ecb \u1ea3nh h\u01b0\u1edfng. Ph\u1eabu thu\u1eadt c\u1eaft b\u1ecf s\u1ebd \u0111\u01b0\u1ee3c xem x\u00e9t khi c\u00e1c t\u1ed5n th\u01b0\u01a1ng c\u00f3 \u1ea3nh h\u01b0\u1edfng nhi\u1ec1u \u0111\u1ebfn sinh ho\u1ea1t c\u1ee7a th\u00fa b\u1ec7nh. Tuy nhi\u00ean s\u1ef1 can thi\u1ec7p ph\u1eabu thu\u1eadt nh\u01b0 v\u1eady \u0111\u00e3 \u0111\u01b0\u1ee3c b\u00e1o c\u00e1o c\u00f3 li\u00ean quan \u0111\u1ebfn nhi\u1ec5m tr\u00f9ng ti\u1ec1m \u1ea9n v\u00e0 t\u0103ng t\u00e1i ph\u00e1t. Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb v\u1edbi interferon (IFN-\u03b1 ho\u1eb7c IFN-\u03c9) \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t b\u1edfi m\u1ed9t s\u1ed1 t\u00e1c gi\u1ea3, nh\u01b0ng c\u00e1c nghi\u00ean c\u1ee9u r\u1ed9ng l\u1edbn ch\u01b0a bao gi\u1edd \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n. T\u00e1c gi\u1ea3 cho r\u1eb1ng IFNs c\u00f3 th\u1ec3 \u0111\u1ea9y nhanh tho\u00e1i h\u00f3a nh\u01b0ng kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng l\u00e0m teo kh\u1ed1i u l\u1ea1i.Tuy nhi\u00ean, ch\u01b0a t\u1eebng c\u00f3 thu\u1ed1c n\u00e0o \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 trong \u0111i\u1ec1u tr\u1ecb m\u1ee5n c\u00f3c ch\u00f3. Duy nh\u1ea5t m\u1ed9t nghi\u00ean c\u1ee9u th\u00fa y v\u1ec1 vi\u1ec7c s\u1eed d\u1ee5ng thu\u1ed1c trong nhi\u1ec5m PV tr\u00ean \u0111\u1ed9ng v\u1eadt \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb sarcoids l\u00e0 \u1edf ng\u1ef1a. V\u00e0 n\u00f3 ch\u1ee9ng minh m\u1ed9t s\u1ed1 hi\u1ec7u qu\u1ea3. Trong m\u1ed9t b\u00e1o c\u00e1o, m\u1ed9t con ch\u00f3 v\u1edbi u nh\u00fa \u1edf mi\u1ec7ng ho\u1eb7c da \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb v\u1edbi azithromycin (10 mg \/ kg \u0111\u01b0\u1eddng u\u1ed1ng m\u1ed7i 24 gi\u1edd trong 10 ng\u00e0y) v\u00e0 c\u1ea3i thi\u1ec7n l\u00e2m s\u00e0ng l\u00e0 th\u1ea5y r\u00f5 so v\u1edbi nh\u1eefng con ch\u00f3 kh\u00f4ng \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb.<\/p>\n

7. PH\u00d2NG B\u1ec6NH<\/strong><\/p>\n

B\u1ea3o v\u1ec7 ch\u1ed1ng l\u1ea1i virus v\u1edbi COPV \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1eb1ng c\u00e1ch li\u00ean t\u1ee5c ch\u1ee7ng ng\u1eeba th\u00f4ng qua chuy\u1ec3n giao DNA l\u00e0 m\u1ed9t plasmid m\u00e3 h\u00f3a protein capsid L1 ch\u00ednh c\u1ee7a COPV ho\u1eb7c protein \u0111\u1ed9t bi\u1ebfn E1 ho\u1eb7c E2 \u0111\u1ebfn c\u00e1c v\u1ecb tr\u00ed da v\u00e0 ni\u00eam m\u1ea1c mi\u1ec7ng c\u1ee7a ch\u00f3 gi\u1ed1ng beagle. Chu\u1ed7i gien codon t\u1ed1i \u01b0u h\u00f3a E1 cung c\u1ea5p s\u1ef1 b\u1ea3o v\u1ec7 \u0111\u1ea7y \u0111\u1ee7 sau khi ti\u00eam ADN cho ch\u00f3 beagle v\u1edbi COPV. C\u1ea3 hai \u0111\u00e1p \u1ee9ng mi\u1ec5n d\u1ecbch trung gian t\u1ebf b\u00e0o v\u00e0 mi\u1ec5n d\u1ecbch d\u1ecbch th\u1ec3 \u0111\u00e3 \u0111\u01b0\u1ee3c ph\u00e1t hi\u1ec7n. Tuy nhi\u00ean vaccine th\u01b0\u01a1ng m\u1ea1i l\u00e0 kh\u00f4ng c\u00f3 s\u1eb5n.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"

1. NGUY\u00caN NH\u00c2N L\u00e0 do virus thu\u1ed9c th\u00e0nh vi\u00ean c\u1ee7a Papillomavirus (PV) v\u1edbi k\u00edch th\u01b0\u1edbc r\u1ea5t nh\u1ecf (30-60 nm), l\u00e0 virus kh\u00f4ng c\u00f3 v\u1ecf envelope v\u1edbi hai m\u01b0\u01a1i m\u1eb7t \u0111\u1ed1i x\u1ee9ng v\u00e0 b\u1ed9 gen v\u00f2ng AND. Ch\u00fang c\u00f3 c\u00f9ng ph\u00e2n lo\u1ea1i v\u1edbi polyomaviruses, trong gia \u0111\u00ecnh Papovaviridae. Ch\u00fang thi\u1ebfu m\u1ed9t l\u1edbp v\u1ecf envelope. PV l\u00e0 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2269","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/posts\/2269","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/comments?post=2269"}],"version-history":[{"count":0,"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/posts\/2269\/revisions"}],"wp:attachment":[{"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/media?parent=2269"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/categories?post=2269"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/robot.yeupet.vn\/index.php\/wp-json\/wp\/v2\/tags?post=2269"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}